Defining a specialized CNS vascular interface
The leptomeningeal blood–cerebrospinal fluid barrier.
This study integrates cross-study transcriptomics, single-nucleus RNA sequencing, and experimental models of neonatal meningitis to distinguish leptomeningeal endothelial cells from cortical blood–brain barrier endothelial cells.
Central finding
A distinct endothelial and stromal program at the meninges.
Leptomeningeal endothelial cells show enhanced extracellular-matrix remodeling and immune-interface programs, reduced canonical Wnt/β-catenin signaling transcripts, and context-dependent remodeling during infection. The atlas makes the study’s supporting cross-study endothelial expression analysis directly explorable.
Built for transparent reuse
Every visual stays connected to its studies and samples.
Curated controls
Only manually reviewed WT and untreated samples enter the analysis.
Consistent processing
All display values are regenerated from GREIN raw counts through one pipeline.
Downloadable evidence
Selected-gene sample values and provenance can be exported for reuse.